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Children's Hospital at Dartmouth Hitchcock (CHad)
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Medication Therapy

There are three medications used to help children with wetting. They do not cure the problem but may help control the condition until the child outgrows it. The medicines may not work for everyone.

  • DDAVP nasal spray or tablets: It works by decreasing the amount of urine your child makes when sleeping. It may be used continuously, every night for several months or for special occasions such as sleepovers or camp.
    Cost: Expensive
    Side Effects: Rare
  • Imipramine (Tofranil®). An antidepressant which also helps with enuresis. We are not certain how it works. It may require a higher dose when using it long term. There is a high relapse rate when discontinued.
    Cost: Inexpensive
    Side effects: May cause anxiety, difficulty sleeping. Overdoses can be fatal. It is being used less frequently due to concerns about its toxicity.
  • Anticholinergics (ie. Levsinex®), work by relaxing the bladder, allowing it to hold more urine. They may be useful in some children with enuresis who have a small bladder capacity and daytime symptoms such as urgency and frequency.
    Cost: Moderate
    Side Effects: Dry mouth, heat sensitivity, flushed cheeks, irritability, blurred vision.

In a small number of children, a combination of both DDAVP and an anticholinergic medication has been used successfully. Also, a combination of an enuresis alarm and medication has been successful in some children.

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